PT  - JOURNAL ARTICLE
AU  - R. H. Buller
AU  - W. T. Rockhold
AU  - J. A. Buzard
AU  - I. J. Stern
TI  - THE POTENTIATING EFFECT OF 4,5-DIHYDRO-6-METHYL-2[2-(4-PYRIDYL)-ETHYL]-3-PYRIDAZINONE (U-320) ON HEXOBARBITAL HYPNOSIS
DP  - 1961 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 95--99
VI  - 134
IP  - 1
4099  - http://jpet.aspetjournals.org/content/134/1/95.short
4100  - http://jpet.aspetjournals.org/content/134/1/95.full
SO  - J Pharmacol Exp Ther1961 Oct 01; 134
AB  - A new agent, 4,5-dihydro-6-methyl-2-[2-(4-pyridyl)ethyl]-3-pyridazinone (U-320), has been found to be a potentiator of hexobarbital. It prolongs plasma and brain levels of hexobarbital qualitatively similar to SKF-525A, but it may be differentiated from this compound by its ability to reinduce sleep in rodents recovering from hexobarbital hypnosis and will induce sleep when combined with subhypnotic doses of hexobarbital.