RT Journal Article
SR Electronic
T1 STUDIES OF ANALGESIC DRUGS: IV. DISSOCIATION OF ANALGESIC, RESPIRATORY AND EMETIC EFFECTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 218
OP 221
VO 130
IS 2
A1 Keats, Arthur S.
A1 Telford, Jane
A1 Kurosu, Yoshio
YR 1960
UL http://jpet.aspetjournals.org/content/130/2/218.abstract
AB The analgesic, respiratory and subjective effects of 4-acetoxy-3-methyl-1-(phenylethyl)-4-0-tolylpiperidine hyrochloride have been studied in man. This compound has demonstrated a remarkable quantitative dissociation in the analgesic, respiratory and emetic activities considered to be obligatory side actions of potent analgesics. In doses which produce analgesia equivalent to morphine, this compound produced severe respiratory depression, minimal nausea and no vomiting. The significance of the demonstration of this dissociation has been discussed.