PT  - JOURNAL ARTICLE
AU  - Borzelleca, Joseph F.
TI  - STUDIES OF THE CONTRIBUTION OF BLADDER ABSORPTION TO THE PHYSIOLOGICAL CHANGES INDUCED BY PENTOBARBITAL
DP  - 1960 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 305--309
VI  - 129
IP  - 3
4099  - http://jpet.aspetjournals.org/content/129/3/305.short
4100  - http://jpet.aspetjournals.org/content/129/3/305.full
SO  - J Pharmacol Exp Ther1960 Jul 01; 129
AB  - The absorption of pentobarbital sodium from the urinary bladders of unanesthetized, catheterized adult, male, mongrel dogs has been demonstrated. The physiological changes taken as an indication that the drug was being absorbed consisted of depression of respiration, ataxia, and the loss of the corneal reflex. Bladder absorption of pentobarbital sodium appears to be dependent upon the state of the bladder mucosa, the extent of bladder distention, and the concentration of the solution employed.