RT Journal Article
SR Electronic
T1 ENZYMATIC PATHWAY FOR THE FORMATION OF COTININE, A MAJOR METABOLITE OF NICOTINE IN RABBIT LIVER
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 94
OP 100
VO 129
IS 1
A1 H. B. Hucker
A1 J. R. Gillette
A1 B. B. Brodie
YR 1960
UL http://jpet.aspetjournals.org/content/129/1/94.abstract
AB A main reaction of nicotine metabolism in rabbit appears to be hydroxylation in the alpha position of the pyrrolidine ring to form a hydroxynicotine. This oxidation occurs in liver microsomes and requires TPNH and O2; the product has the properties of a cyclized amino aldehyde. The hydroxynicotine then undergoes oxidation to cotinine, a reaction that may be catalyzed by an aldehyde oxidase.