PT  - JOURNAL ARTICLE
AU  - Joy Paul-David
AU  - Jean-Louis Riehl
AU  - Klaus R. Unna
TI  - QUANTIFICATION OF EFFECTS OF DEPRESSANT DRUGS ON EEG ACTIVATION RESPONSE
DP  - 1960 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 69--74
VI  - 129
IP  - 1
4099  - http://jpet.aspetjournals.org/content/129/1/69.short
4100  - http://jpet.aspetjournals.org/content/129/1/69.full
SO  - J Pharmacol Exp Ther1960 May 01; 129
AB  - Quantification of the effects of different CNS depressants on the EEG activation response evoked by electrical stimulation of the medial reticular formation has been studied in encéphale isolé cat preparations. Quantitative relationships were established between stimulus strength and the EEG activation response, and dose-response curves were constructed for atropine, atropine methylnitrate, pentobarbital and chlorpromazine. Depression of the EEG activation could be demonstrated with threshold doses of 0.2 mg/kg for atropine and 1 mg/kg for atropine methylnitrate. The threshold dose for chlorpromazine was 0.5 mg/kg and for pentobarbital, 1 mg/kg. Atropine methylnitrate was found to have an action on the CNS similar to that of atropine; its low potency and latency of action may be attributed to the slow diffusibility of the quaternary nitrogen configuration.