TY - JOUR T1 - PHARMACOLOGIC STUDIES OF A NEW ANTITUSSIVE, <em>ALPHA</em> (DIMETHYLAMINOETHYL)-<em>ORTHO</em>-CHLOROBENZHYDROL HYDROCHLORIDE (SL-501, BAYER B-186) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 384 LP - 391 VL - 128 IS - 4 AU - James Y. P. Chen AU - Hugh F. Biller AU - Edwin G. Montgomery, Jr. Y1 - 1960/04/01 UR - http://jpet.aspetjournals.org/content/128/4/384.abstract N2 - The relative antitussive efficacies of alpha (dimethylaminoethyl)-ortho-chlorobenzhydrol hydrochloride (SL-501, Bayer B-186), codeine, dihydrocodeinone and several currently used nonnarcotic antitussives have been appraised by a method in which experimental cough was induced by aerosolized N sulfuric acid in unanesthetized dogs. SL-501, a new nonnarcotic antitussive, shows a potent and long-acting cough-suppressing activity in dogs. It has a relatively slower onset of maximum action than the narcotics. SL-501 exhibits moderate local anesthetic effects and a mild antispasmodic action. It also causes some prolongation of sleeping time in pentobarbitalized mice. No analgesic, sedative-hypnotic, antihistaminic or antiemetic properties were demonstrated. Acute and chronic toxicity studies in animals indicate that SL-501 is relatively nontoxic, and has a high therapeutic ratio. ER -