TY - JOUR T1 - PHARMACOLOGICAL AND ACUTE TOXICOLOGICAL COMPARISONS OF TRIFLUPROMAZINE AND CHLORPROMAZINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 55 LP - 65 VL - 127 IS - 1 AU - Joseph J. Piala AU - John P. High AU - G. Lee Hassert, Jr. AU - John C. Burke AU - Bradford N. Craver Y1 - 1959/09/01 UR - http://jpet.aspetjournals.org/content/127/1/55.abstract N2 - Triflupromazine (TFP) and chlorpromazine (CPZ) exhibited comparable acute toxicities in mice, rats and dogs except following intravenous administration when CPZ was more toxic in mice and less toxic in dogs. In small animals and in in vitro studies measurements of general depressant activity as well as of synergism with or antagonism toward other drugs indicated similar qualitative and quantitative actions for these two phenothiazines. More highly differentiated procedures in rats, monkeys and dogs, however, evidenced the higher potency of TFP as a tranquilizing and antiemetic agent and indicated less likelihood of cardiovascular side actions. ER -