PT  - JOURNAL ARTICLE
AU  - John N. Bickers
AU  - E. H. Bresler
AU  - Robert Weinberger
TI  - THE ACUTE EFFECT OF AN ORGANIC MERCURIAL ON THE RAT KIDNEY; A HISTOCHEMICAL STUDY
DP  - 1960 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 283--288
VI  - 128
IP  - 3
4099  - http://jpet.aspetjournals.org/content/128/3/283.short
4100  - http://jpet.aspetjournals.org/content/128/3/283.full
SO  - J Pharmacol Exp Ther1960 Mar 01; 128
AB  - The effect of meralluride was studied on a group of 5 renal tubular enzyme systems; succinic dehydrigenase, diphosphopyridine nucleotide diaphorase, triphosphopyridine nucleotide diaphorase, glucose-6-phosphatase, and beta-glyeeryl-phosphatase. Reproducible patterns of inhibition or change in the distribution of enzymatic a ctivity were produced by varying dosages and periods of exposure. The suceptibility to change was strikingly similar in all 5 members of the group. In no instance was enzymatic activity modified without definite mercurial nephropathy being present on standard hematoxylin-cosin sections. The significance of these findings was discussed particularly in regard to the purported role of succinie dehydrogenase in mercurial pharmacology.