RT Journal Article
SR Electronic
T1 AMINO-METHYLCHROMONES, BRAIN STEM STIMULANTS AND PENTOBARBITAL ANTAGONISTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 176
OP 181
VO 128
IS 2
A1 I. Setnikar
A1 W. Murmann
A1 M. J. Magistretti
A1 P. Da Re
YR 1960
UL http://jpet.aspetjournals.org/content/128/2/176.abstract
AB The CNS stimulant activity of two new brain stem stimulants, 2,3-dimethyl-7-methoxy-morpholinomethylchromone hydrochloride (Rec 7- 0105) and 3-methyl-7-methoxy-8-dimethylamino-methylflavone hydrochloride (Rec 7-0267, dimefline) are compared with other brain stem stimulants of known efficacy and with other CNS stimulants. The capacity of all the drugs under examination for antagonizing the toxic effects of pentobarbital is described. Only brain stem stimulants are capable of exerting a true antagonism to this barbiturate. The two new drugs are more active thanbemegride, picrotoxin and Metrazol.