PT  - JOURNAL ARTICLE
AU  - Ralph D. Tanz
AU  - James W. Bray
AU  - Jacqueline H. Hill
TI  - STUDIES ON THE ACTION OF CORTISONE ACETATE ON ISOLATED CARDIAC TISSUE
DP  - 1960 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 168--175
VI  - 128
IP  - 2
4099  - http://jpet.aspetjournals.org/content/128/2/168.short
4100  - http://jpet.aspetjournals.org/content/128/2/168.full
SO  - J Pharmacol Exp Ther1960 Feb 01; 128
AB  - The action of cortisone upon the isolated cat papillary muscle and isolated whole heart preparations was investigated. The results show that small doses (1 µg/ml) tend to restore the amplitude of contractions to control levels in the isolated heart preparation, and offer histological protection to papillary muscles. This effect is referred to as a "protective" or "normalizing" action. The addition of "toxic" doses of cortisone (40 µg/ml), often resulted in abnormal papillary muscle contractile patterns about an hour and a half after administration. One of these patterns was the production of a marked augmentation following suprathreshold stimulation. Cursory experiments into the nature of this phenomena implicate the endogenous release of adrenergic mediators. A "toxic" dose of cortisone also brought about a negative inotropic response of both papillary muscle and intact heart preparations.