PT  - JOURNAL ARTICLE
AU  - Elizabeth Cox
AU  - S. E. Wright
TI  - THE HEPATIC EXCRETION OF DIGITALIS GLYCOSIDES AND THEIR GENINS IN THE RAT
DP  - 1959 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 117--122
VI  - 126
IP  - 2
4099  - http://jpet.aspetjournals.org/content/126/2/117.short
4100  - http://jpet.aspetjournals.org/content/126/2/117.full
SO  - J Pharmacol Exp Ther1959 Jun 01; 126
AB  - The biliary excretion of lanatoside A, lanatoside C, digitoxin, digoxin, digitoxigenin and digoxigenin in rats has been examined by paper chromatographic and colorimetric methods. In bile lanatosides A and C were excreted unchanged. Digitoxin, digoxin and digoxigenin were present partly unaltered and partly as metabolites which still retained the unsaturated lactone ring. Digitoxigenin was excreted entirely as metabolites. The amount of glycoside or aglycone and their metabolites present in the bile within 5 hours of glycoside administration was determined. This ranged from 70 to 80% of the dose for lanatosides A and C to about 10% for digitoxin. About 15% of the dose of each aglycone was excreted in bile. The relationship between the biliary excretion and the structure of these substances is discussed.