TY - JOUR T1 - THE KINETICS OF DEPRESSION OF POTASSIUM OUTFLUX BY COCAINE IN TOAD SCIATIC NERVE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 316 LP - 322 VL - 125 IS - 4 AU - Abraham M. Shanes AU - Morris D. Berman Y1 - 1959/04/01 UR - http://jpet.aspetjournals.org/content/125/4/316.abstract N2 - The outflux of potassium in metabolizing, desheathed, sciatic nerves of the toad, Bufo marinus, undergoes only a transitory decline upon application of 0.1% cocaine. However, when the outflux has been increased previously by a combination of anoxia and iodoacetate poisoning, cocaine produces a sustained depression of this outflux. These observations seem accounted for qualitatively by the postulate that only the outermost layer of the membrane is affected by the local anesthetic, the permeability to both potassium and sodium being reduced in this restricted region. ER -