RT Journal Article
SR Electronic
T1 THE INFLUENCE OF ACIDOSIS AND ALKALOSIS ON MERCURIAL-INDUCED DIURESIS AND SULFHYDRYL CHANGES IN THE KIDNEY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 309
OP 315
VO 125
IS 4
A1 Farah, A.
A1 Bender, C. H.
A1 Kruse, R.
A1 Cafruny, E.
YR 1959
UL http://jpet.aspetjournals.org/content/125/4/309.abstract
AB The effects of changes in acid-base balance on mersalyl- and mercury bichloride-induced diuresis and renal cellular protein-bound sulfhydryl changes have been determined in rats and dogs. In dogs alkalosis decreases mersalyl-induced sulfhydryl changes and diuresis when compared with acidotic animals. Changes in acid-basebalance do not influence mercury bichlorideinduced renal cellular sulfhydryl changes in the terminal part of the proximal tubule although alkalosis depresses mercury bichloride-induced diuresis as compared to acidotic dogs. The results are compatible with the interpretation that with the organic mercurial diuretics a splitting of the carbon-mercury bond may be operative; however, other factors such as electrolyte load are also important in determining the extent of a mercurial diuresis.