PT  - JOURNAL ARTICLE
AU  - Farah, A.
AU  - Bender, C. H.
AU  - Kruse, R.
AU  - Cafruny, E.
TI  - THE INFLUENCE OF ACIDOSIS AND ALKALOSIS ON MERCURIAL-INDUCED DIURESIS AND SULFHYDRYL CHANGES IN THE KIDNEY
DP  - 1959 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 309--315
VI  - 125
IP  - 4
4099  - http://jpet.aspetjournals.org/content/125/4/309.short
4100  - http://jpet.aspetjournals.org/content/125/4/309.full
SO  - J Pharmacol Exp Ther1959 Apr 01; 125
AB  - The effects of changes in acid-base balance on mersalyl- and mercury bichloride-induced diuresis and renal cellular protein-bound sulfhydryl changes have been determined in rats and dogs. In dogs alkalosis decreases mersalyl-induced sulfhydryl changes and diuresis when compared with acidotic animals. Changes in acid-basebalance do not influence mercury bichlorideinduced renal cellular sulfhydryl changes in the terminal part of the proximal tubule although alkalosis depresses mercury bichloride-induced diuresis as compared to acidotic dogs. The results are compatible with the interpretation that with the organic mercurial diuretics a splitting of the carbon-mercury bond may be operative; however, other factors such as electrolyte load are also important in determining the extent of a mercurial diuresis.