PT  - JOURNAL ARTICLE
AU  - F. Barbara Hughes
AU  - Bernard B. Brodie
TI  - THE MECHANISM OF SEROTONIN AND CATECHOLAMINE UPTAKE BY PLATELETS
DP  - 1959 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 96--102
VI  - 127
IP  - 2
4099  - http://jpet.aspetjournals.org/content/127/2/96.short
4100  - http://jpet.aspetjournals.org/content/127/2/96.full
SO  - J Pharmacol Exp Ther1959 Oct 01; 127
AB  - Attempts to demonstrate the existence of a serotonin complex in suspensions of lysed rabbit platelets have not been successful. However, kinetic studies of serotonin uptake by platelets of normal and reserpine-treated guinea pigs indicate that serotonin is taken up by active transfer. Reserpine appears to act by blocking the active transport. Norepinephrine and epinephrine, but not bufotenine, can also be taken up in platelets in vitro by a process which is blocked by reserpine.