RT Journal Article
SR Electronic
T1 CONCENTRATION OF FREE AND CONJUGATED MORPHINE IN BRAIN AND OTHER TISSUES OF TOLERANT AND NONTOLERANT RABBITS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 252
OP 254
VO 124
IS 3
A1 ROBERT SIMINOFF
A1 PAUL R. SAUNDERS
YR 1958
UL http://jpet.aspetjournals.org/content/124/3/252.abstract
AB Existing methods for the determination of morphine in tissues have been modified to permit the determination of the low concentrations of drug present in the brain after the administration of moderate doses. The method has been applied to a study of the concentration of free morphine in the brain and of free and bound drug in the liver, kidney and blood of tolerant and nontolerant rabbits. No difference was found in the concentration of morphine in tolerant as compared to nontolerant rabbits, at intervals of 1/2, 1, 2, 4 and 8 hours after intraperitoneal administration of the drug. © 1958, by The Williams & Wilkins Company