TY - JOUR T1 - HEART LESIONS IN MICE CAUSED BY TREATMENT WITH BISHYDROXYCOUMARIN (DICUMAROL) JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 182 LP - 187 VL - 124 IS - 2 AU - F. I. Dessau AU - S. Klein AU - L. Lipchuck AU - J. O'Grady AU - J. Tsalikis Y1 - 1958/10/01 UR - http://jpet.aspetjournals.org/content/124/2/182.abstract N2 - Dicumarol added to either purified, or pellet diets, at levels from 40 to 200 mg/kg diet, induced heart muscle lesions in mice resembling those observed in mice kept on sulfaguanidine-supplemented purified diets. Vitamin E supplements to the diet did not modify the effect of Dicumarol (200 mg/kg), while this effect was prevented by vitamin K1 at 2 times, or Menadione at 8 times the dietary level of Dicumarol. The addition of vitamin E to a diet containing Menadione at twice the level of Dicumarol did not alter the effect of Dicumarol. ER -