PT  - JOURNAL ARTICLE
AU  - Leslie E. Geiger
AU  - Peter Cervoni
AU  - Joseph R. Bertino
AU  - Frank Monteleone
TI  - ACTION OF ZOXAZOLAMINE UPON SPINAL SEGMENTAL REFLEXES
DP  - 1958 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 164--170
VI  - 123
IP  - 2
4099  - http://jpet.aspetjournals.org/content/123/2/164.short
4100  - http://jpet.aspetjournals.org/content/123/2/164.full
SO  - J Pharmacol Exp Ther1958 Jun 01; 123
AB  - The effects of zoxazolamine upon reflex discharges in ventral roots of spinal cats were examined. Two-and three-neurone ares were inhibited by intravenous injection of 30 to 40 mgm./kgm. zoxazolamine. Complexes in ventral roots representing 4- and 5-neurone reflexes or reflexes mediated by slowly conducting fibers were inhibited by intravenuous injection of 15-30 mgm./kgm.zoxazolamuuine. Prolonged repetitive activity in ventral root filments in response to intense dorsal root stimulation was also decreased at these doses. The amount of zoxazolamine which is sufficient to depress the withdrawal reflex also inhibits the rate of repetitive discharge of motoneurones. The possible sites of action of zoxazolamine are discussed.