RT Journal Article
SR Electronic
T1 XVI. DIFFERENCES IN THE ACTION OF DRUGS ON DIFFERENT PARTS OF THE BOWEL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 171
OP 191
VO 12
IS 3
A1 WALTER C. ALVAREZ
YR 1918
UL http://jpet.aspetjournals.org/content/12/3/171.abstract
AB Five segments excised from different parts of the rabbit's intestine have been studied under identioal conditions in warm aerated Locke's solution. Seventy-six substances were tested. Some affected all the segments about equally, while others affected them unequally and even dissimilarly. A number produced effects more or less graded from one end of the tract to the other. It is suggestive that a number of the drugs which through their graded actions might tend to steepen the intestinal gradient are used as laxatives, and a number of those which might tend to reverse the gradient are well-known emetics. Some of the drugs affected the colon particularly. Others had a peculiarly depressant effect on the jejunum. A list of convenient dosages is appended.