PT  - JOURNAL ARTICLE
AU  - WALTER C. ALVAREZ
TI  - XVI. DIFFERENCES IN THE ACTION OF DRUGS ON DIFFERENT PARTS OF THE BOWEL
DP  - 1918 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 171--191
VI  - 12
IP  - 3
4099  - http://jpet.aspetjournals.org/content/12/3/171.short
4100  - http://jpet.aspetjournals.org/content/12/3/171.full
SO  - J Pharmacol Exp Ther1918 Oct 01; 12
AB  - Five segments excised from different parts of the rabbit's intestine have been studied under identioal conditions in warm aerated Locke's solution. Seventy-six substances were tested. Some affected all the segments about equally, while others affected them unequally and even dissimilarly. A number produced effects more or less graded from one end of the tract to the other. It is suggestive that a number of the drugs which through their graded actions might tend to steepen the intestinal gradient are used as laxatives, and a number of those which might tend to reverse the gradient are well-known emetics. Some of the drugs affected the colon particularly. Others had a peculiarly depressant effect on the jejunum. A list of convenient dosages is appended.