RT Journal Article
SR Electronic
T1 STUDIES ON THE METABOLISM OF NORNICOTINE IN THE DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 259
OP 262
VO 123
IS 4
A1 Howard B. Hucker
A1 P. S. Larson
YR 1958
UL http://jpet.aspetjournals.org/content/123/4/259.abstract
AB Total per cent excretion of nornicotine in the urine increases with increasing dosage up to a peak of approximately 60 per cent at dose levels of 15 mgm./kgm. and above. The rate of urinary excretion of nornicotine increases with increasing dosage. The rate of detoxication of nornicotine appears to be independent of dosage at the levels studied. Urinary excretion of nornicotine is virtually complete within 16 hours after cessation of administration. The intravenous LD50 of nornicotine in dogs is 4.0 mgm./kgm.