PT  - JOURNAL ARTICLE
AU  - Graham Chen
AU  - Barbara Bohner
TI  - A STUDY OF CENTRAL NERVOUS SYSTEM STIMULANTS
DP  - 1958 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 212--215
VI  - 123
IP  - 3
4099  - http://jpet.aspetjournals.org/content/123/3/212.short
4100  - http://jpet.aspetjournals.org/content/123/3/212.full
SO  - J Pharmacol Exp Ther1958 Jul 01; 123
AB  - A number of CNS stimulants have been investigated under two main categories based on whether or not they produce tonic extensor seizures in mice. Among the tonic extensor seizure producing agents, 10-(2-dimethylaminopropyl)-9-acridone and hydralazine are shown to be picrotoxin-like, while 4-methyl-4-ethylglutarimide and α,α,β,β- tetramethylsuccinimide are pentylenetetrazollike convulsants. A comparative study has been carried out with the following excitants: diphenhydramine, cocaine, methyiphenidate, pipradrol, desoxyephedrine, ibogaine, lysergic acid diethylamide and 1,4-dipyrrolidino-2-butyne. They are incapable of inducing tonic extensor seizures in mice. The stimulant effects of these compounds differ by the running movements, (disorderly or coordinated), by the intensity of tremors and by the presence or absence of piloerection and salivation. With the exception of the last two compounds, the other excitants are capable of suppressing electrically or pentylenetetrazol-induced tonic extensor seizures in mice but are ineffective in suppressing strychnine-or caffeine-induced tonic extensor seizures.