RT Journal Article
SR Electronic
T1 THE DETOXIFYING ACTION OF SODIUM SALT ON POTASSIUM SALT IN THE GUINEA PIG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 19
OP 35
VO 12
IS 1
A1 SAMUEL AMBERG
A1 HENRY F. HELMHOLZ
YR 1918
UL http://jpet.aspetjournals.org/content/12/1/19.abstract
AB Guinea-pigs survive the intravenous injection of otherwise fatal doses of KCl and K2SO4 if they are administered in mixtures with NaCl. The same effect is noted when Na2SO4 is added to KCl solution. The effect is, however, not quite so marked. In these experiments the concentration of the Na2SO4 was equal to that of the 5 per cent NaCl solution with reference to its Na content. An equal concentration of sodium acetate does not afford any protection against the KCl intoxication. The protection offered by NaCl against NH4Cl is somewhat doubtful, at any rate it is much less marked than against KCl. The presence of 50 per cent glucose in the KCl solution protects the animals very markedly. A usual fatal dose of KCl or K2SO4 injected soon after an injection of 5 per cent NaCl, is tolerated, while a previous injection of 0.55 per cent NaCl does not protect, or only very rarely. Where a previous injection of Na2SO4 is tolerated it may also protect against KCl. The previous injection of NaCl seems to protect against NH4Cl. Several possibilities which may contribute to such protective actions, as are here described, are pointed out. The intravenous injection of 10 per cent NaCl solution in proper dosage produces a clouding of the crystalline lens. This cloudiness appears within about twenty minutes and disappears in the course of about four hours.