PT  - JOURNAL ARTICLE
AU  - Hogben, C. Adrian M.
AU  - Schanker, Lewis S.
AU  - Tocco, Dominick J.
AU  - Brodie, Bernard B.
TI  - ABSORPTION OF DRUGS FROM THE STOMACH. II. THE HUMAN
DP  - 1957 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 540--545
VI  - 120
IP  - 4
4099  - http://jpet.aspetjournals.org/content/120/4/540.short
4100  - http://jpet.aspetjournals.org/content/120/4/540.full
SO  - J Pharmacol Exp Ther1957 Aug 01; 120
AB  - The human stomach is capable of absorbing most acidic drugs and the very weakly basic drugs. Salicylic acid, aspirin, thiopental, secobarbital and antipyrine, which are undissociated in the acidic gastric contents, were readily absorbed. Phenol red, quinine, ephedrine and aminopyrine, which are almost completely ionized in acid solution were not absorbed. These results are compatible with the hypothesis that drugs are absorbed by passive diffusion of their lipid soluble undissociated form. Many drugs may be absorbed by the human stomach as rapidly or more rapidly than ethyl alcohol.