RT Journal Article
SR Electronic
T1 PHARMACOLOGY OF SOME NEW UNSYMMETRICAL BISQUATERNARY HYPOTENSIVE AGENTS—SUBSTITUTED PYRIDINE AND PIPERIDINE DERIVATIVES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 438
OP 446
VO 120
IS 4
A1 Thomas B. O'Dell
A1 Martha D. Napoli
YR 1957
UL http://jpet.aspetjournals.org/content/120/4/438.abstract
AB Pharmacological studies on some new substituted pyridine and piperidine unsymmetrical bisquaternary compounds have been described. Several of these compounds are potent hypotensive agents with such action being found in some cases with intravenous doses as low as 10 to 25 microgm./kgm. It was found that relatively minor structural modifications can markedly alter the degree of hypotensive activity and to a lesser extent the degree of sympathetic ganglionic blockage or acute toxicity. Mechanism studies are described and the results indicate that the sustained hypotensive effect of these compounds involves primarily an action at some central site.