PT  - JOURNAL ARTICLE
AU  - James L. Leitch
AU  - D. Maryn
AU  - V. G. Debley
AU  - Thomas J. Haley
TI  - INFLUENCE OF pH AND ATROPINE ON THE RESPONSE OF SUPERFUSED TISSUES TO 5-HYDROXYTRYPTAMINE AND ACETYLCHOLINE
DP  - 1957 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 408--411
VI  - 120
IP  - 4
4099  - http://jpet.aspetjournals.org/content/120/4/408.short
4100  - http://jpet.aspetjournals.org/content/120/4/408.full
SO  - J Pharmacol Exp Ther1957 Aug 01; 120
AB  - A study has been made of the effects of pH of the superfusate and atropine concentration on the responses of the superfused rat uterus and the guinea pig ileum to 5-hydroxytryptamine and acetylcholine. The rat uterus is more sensitive to 5-hydroxytryptamine and acetylcholine than the guinea pig ileum. It is possible to estimate the amount of 5-hydroxytryptamine in the presence of acetylcholine by the selection of a concentration of atropine which blocks the latter and only slightly diminishes the responses to the former. It has been shown that a more acid pH decreases the sensitivity of the rat uterus to both acetyicholine and 5-hydroxytryptamine and increases its sensitivity to atropine.