PT  - JOURNAL ARTICLE
AU  - Donald L. Cook
AU  - Coleta A. Lawler
AU  - John W. Cusic
TI  - RELATION OF PERIPHERAL VASODILATOR ACTIVITY TO CHEMICAL STRUCTURE OF 1,2,3,4-TETRAHYDROISOQUINPLINE DERIVATIVES
DP  - 1957 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 269--275
VI  - 120
IP  - 3
4099  - http://jpet.aspetjournals.org/content/120/3/269.short
4100  - http://jpet.aspetjournals.org/content/120/3/269.full
SO  - J Pharmacol Exp Ther1957 Jul 01; 120
AB  - Peripheral vasodilator activity of a series of 1,2,3,4-tetrahydroisoquinoline (THIQ) derivatives was studied in the dog. The series included four chemical types: aliphatic, heterocydic, ester and ether. Activity was found in all types. The most active compound was a heterocycic derivative, N-beta-hydroxyethyl-THIQ-2-thenyl ether, which was forty-five times as active as the parent compound (THIQ). This compound was also found to possess potent adrenergic blocking activity.