RT Journal Article
SR Electronic
T1 EFFECT OF IPRONIAZID ON SEROTONIN METABOLISM <em>IN VIVO</em>
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 255
OP 260
VO 120
IS 2
A1 Udenfriend, Sidney
A1 Weissbach, Herbert
A1 Bogdanski, Donald F.
YR 1957
UL http://jpet.aspetjournals.org/content/120/2/255.abstract
AB Administration of 1-isopropyl-2-isonicotinyl hydrazide (iproniazid) to animals has been shown to produce a 2-to 3-fold increase in endogenous brain serotonin and to increase the amounts of serotonin appearing in brain following 5HTP. However, iproniazid has little effect on peripheral depots of serotonin or on the metabolism of serotonin or tyramine when they are administered parenterally. This is due to its inability to penetrate to the site of monoamine oxidase in intact cells. © 1957 by The Williams &amp; Wilkins Co.