RT Journal Article
SR Electronic
T1 CARDIOVASCULAR ACTION OF HYDROXYZINE (ATARAX)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 451
OP 460
VO 118
IS 4
A1 D. E. Hutcheon
A1 A. Scriabine
A1 D. L. Morris
YR 1956
UL http://jpet.aspetjournals.org/content/118/4/451.abstract
AB Hydroxyzine in doses of 1.2 - 20 mgm./kgm. intravenously caused a transient fall in arterial blood pressure and inhibited the pressor response to epinephrine in cats under pentobarbital anesthesia. Hydroxyzine reduced the incidence and duration of ventricular arrhythmias in cats treated with harman methosulfate and epinephrine. Hydroxyzine increased the coronary flow in the perfused cat's heart and in the hearts of dogs under anesthesia. The femoral blood vessels were also dilated by hydroxyzine. Epinephrine-induced automaticity of papillary muscles and isolated auricular strips was prevented by hydroxyzine in concentrations which did not significantly affect the threshold of electrical excitability.