RT Journal Article
SR Electronic
T1 SOME STUDIES ON ESTROGENS AND UTERINE PERMEABILITY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 442
OP 448
VO 115
IS 4
A1 Sumner M. Kalman
YR 1955
UL http://jpet.aspetjournals.org/content/115/4/442.abstract
AB Ovariectomized Long-Evans rats treated with ethinyl estradiol four hours before sacrifice showed an uptake of I131 by the uterus commensurate with this organ's increase in water content. The uptake of Na22, however, was greater than could be accounted for by the increased water content. By intracardiac injection of I131 labeled serum albumin a remarkably large penetration of this material into the estrogen-treated uterus was shown. To prove that this increase was due to a change in capillary permeability Cr51 labeled red cells were injected into the blood stream: the distribution of the labeled blood cells indicated no appreciable difference between the vascular pool of the uterus in treated or control groups.