PT - JOURNAL ARTICLE AU - Sumner M. Kalman TI - SOME STUDIES ON ESTROGENS AND UTERINE PERMEABILITY DP - 1955 Dec 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 442--448 VI - 115 IP - 4 4099 - http://jpet.aspetjournals.org/content/115/4/442.short 4100 - http://jpet.aspetjournals.org/content/115/4/442.full SO - J Pharmacol Exp Ther1955 Dec 01; 115 AB - Ovariectomized Long-Evans rats treated with ethinyl estradiol four hours before sacrifice showed an uptake of I131 by the uterus commensurate with this organ's increase in water content. The uptake of Na22, however, was greater than could be accounted for by the increased water content. By intracardiac injection of I131 labeled serum albumin a remarkably large penetration of this material into the estrogen-treated uterus was shown. To prove that this increase was due to a change in capillary permeability Cr51 labeled red cells were injected into the blood stream: the distribution of the labeled blood cells indicated no appreciable difference between the vascular pool of the uterus in treated or control groups.