RT Journal Article
SR Electronic
T1 DILATOR RESPONSES TO ISOPROTERENOL IN CUTANEOUS AND SKELETAL MUSCLE VASCULAR BEDS; EFFECTS OF ADRENERGIC BLOCKING DRUGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 323
OP 328
VO 115
IS 3
A1 Paul A. Walters, Jr.
A1 Thomas W. Cooper
A1 Adam B. Denison, Jr.
A1 Harold D. Green
YR 1955
UL http://jpet.aspetjournals.org/content/115/3/323.abstract
AB By means of the electromagnetic flowmeter, the vasomotor responses to intra-arterial injections of isoproterenol were compared to those of epinephrine and levarterenol in cutaneous and skeletal muscle vascular beds before and during blockade with azapetine (llidar) and phenoxybenzamine (Dibenzyline). Isoproterenol caused vasodilation in both beds. In skins, the dilator responses to isoproterenol were blocked by approximately the same dose as that which blocked the constrictor responses to epinephrine and levarterenol, i.e., 10 mgm./kgm. of phemioxybenzamine and 30 mgm./kgm. of azapetine. In muscle, the dilator responses to isoproterenol were blocked at the same dose that. abolished the dilator responses to epinephrine, i.e., 1 mgm./kgm. of phenoxybenzamine and 60 mgm./kgm. of azapetine. These were approximately 20 times the dose required to block the constrictor responses to levarterenol. It was suggested that epinephrine behaves as if it were a composite of both levarterenol au isoprotenol.