RT Journal Article
SR Electronic
T1 THE EFFECTS OF REDUCED GLUTATHIONE AND RELATED SUBSTANCES ON THE THRESHOLD OF IRRITABILITY OF MAMMALIAN VENTRICULAR MUSCLE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 300
OP 304
VO 115
IS 3
A1 Garb, Solomon
A1 Scriabine, Alexander
A1 Penna, Mario
A1 Fujimori, Hiroshi
A1 Kirk, Ann
A1 Hardy, Robert
YR 1955
UL http://jpet.aspetjournals.org/content/115/3/300.abstract
AB Reduced glutathione produced a marked lowering of the threshold of irritability of the cat papillary muscle but did not change contractile force. On the other hand, methionine did not change irritability but increased contractile force. Cysteine lowered the threshold of irritability and increased contractile force. These findings suggest that different metabolic cycles may be involved in furnishing energy for the various aspects of cardiac muscle function. Reduced glutathione may prove useful in some cases of diminished ventricular irritability.