PT  - JOURNAL ARTICLE
AU  - Garb, Solomon
AU  - Scriabine, Alexander
AU  - Penna, Mario
AU  - Fujimori, Hiroshi
AU  - Kirk, Ann
AU  - Hardy, Robert
TI  - THE EFFECTS OF REDUCED GLUTATHIONE AND RELATED SUBSTANCES ON THE THRESHOLD OF IRRITABILITY OF MAMMALIAN VENTRICULAR MUSCLE
DP  - 1955 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 300--304
VI  - 115
IP  - 3
4099  - http://jpet.aspetjournals.org/content/115/3/300.short
4100  - http://jpet.aspetjournals.org/content/115/3/300.full
SO  - J Pharmacol Exp Ther1955 Nov 01; 115
AB  - Reduced glutathione produced a marked lowering of the threshold of irritability of the cat papillary muscle but did not change contractile force. On the other hand, methionine did not change irritability but increased contractile force. Cysteine lowered the threshold of irritability and increased contractile force. These findings suggest that different metabolic cycles may be involved in furnishing energy for the various aspects of cardiac muscle function. Reduced glutathione may prove useful in some cases of diminished ventricular irritability.