RT Journal Article
SR Electronic
T1 THE METABOLISM OF BUTABARBITAL (BUTISOL) IN THE DOG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 275
OP 282
VO 115
IS 3
A1 Maynert, E. W.
A1 Losin, Laura
YR 1955
UL http://jpet.aspetjournals.org/content/115/3/275.abstract
AB Specific methods for the determination of hutabarbital in plasma and urine are described. Butabarbital disappears from the plasma of dogs at a rate of about 6 per cent per hour. This rate, which is intermediate between those for barbital and pentobarbital, supports the concept that the length of depressant action of a dialkylbarbiturate depends to a considerable extent upon the duration of its sojourn in the body. Unchanged butabarhital equivalent to 3-5 per cent of the dose could be detected in the urine. A metabolite which was proved to be 5-ethyl, 5(1-methyl, 2-carboxyethyl)-barbituric acid was isolated from urine. Two dogs excreted this compound in amounts corresponding to 28 and 35 per cent of a dose of butabarbital. Butabarbital causes increased amounts of glucuronides to appear in urine.