PT  - JOURNAL ARTICLE
AU  - Maynert, E. W.
AU  - Losin, Laura
TI  - THE METABOLISM OF BUTABARBITAL (BUTISOL) IN THE DOG
DP  - 1955 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 275--282
VI  - 115
IP  - 3
4099  - http://jpet.aspetjournals.org/content/115/3/275.short
4100  - http://jpet.aspetjournals.org/content/115/3/275.full
SO  - J Pharmacol Exp Ther1955 Nov 01; 115
AB  - Specific methods for the determination of hutabarbital in plasma and urine are described. Butabarbital disappears from the plasma of dogs at a rate of about 6 per cent per hour. This rate, which is intermediate between those for barbital and pentobarbital, supports the concept that the length of depressant action of a dialkylbarbiturate depends to a considerable extent upon the duration of its sojourn in the body. Unchanged butabarhital equivalent to 3-5 per cent of the dose could be detected in the urine. A metabolite which was proved to be 5-ethyl, 5(1-methyl, 2-carboxyethyl)-barbituric acid was isolated from urine. Two dogs excreted this compound in amounts corresponding to 28 and 35 per cent of a dose of butabarbital. Butabarbital causes increased amounts of glucuronides to appear in urine.