RT Journal Article
SR Electronic
T1 BIOTRANSFORMATION PRODUCTS OF MEPERIDINE EXCRETED IN THE URINE OF MAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 414
OP 419
VO 117
IS 4
A1 N. P. Plotnikoff
A1 E. Leong Way
A1 H. W. Elliott
YR 1956
UL http://jpet.aspetjournals.org/content/117/4/414.abstract
AB Employing the Brodie methyl orange and the Craig countercurrent techniques it was shown that meperidine is hydrolyzed and excreted in the urine of man as meperidinic acid and its corresponding acid conjugate. In addition, meperidine is demethylated to normeperidine which is then hydrolyzed to normeperidinic acid and partially conjugated.