RT Journal Article
SR Electronic
T1 STUDIES ON VERATRUM ALKALOIDS. XXIV. THE INHIBITION BY VERATRAMINE AND VERATROSINE OF THE CARDIOACCELERATOR EFFECT OF ELECTRICAL STIMULATION OF THE ACCELERATOR TOR NERVES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 317
OP 321
VO 117
IS 3
A1 I. R. Innes
A1 H. W. Kosterlitz
A1 O. Krayer
YR 1956
UL http://jpet.aspetjournals.org/content/117/3/317.abstract
AB Veratramine and veratrosine injected in spinal cats in doses of 0.1 to 0.3 mgm./kgm. lower the basal heart rate and diminish the increase in rate due to stimulation of the accelerator nerves. Although these two effects usually occur simultaneously, they are not necessarily interrelated. The basal heart rate decreases more slowly after injections of veratrosine than after veratramine. Apart from this, the effects of the two drugs on the heart rate and the accelerator responses appear to be similar. Chronic sympathetic denervation of the heart does not fundamentally alter the effect of veratramine on the basal heart rate and on the accelerator action of epinephrine.