PT  - JOURNAL ARTICLE
AU  - Edmund G. Anderson
AU  - Donald F. Magee
TI  - A STUDY OF THE MECHANISM OF THE EFFECT OF DIETARY FAT IN DECREASING THIOPENTAL SLEEPING TIME
DP  - 1956 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 281--286
VI  - 117
IP  - 3
4099  - http://jpet.aspetjournals.org/content/117/3/281.short
4100  - http://jpet.aspetjournals.org/content/117/3/281.full
SO  - J Pharmacol Exp Ther1956 Jul 01; 117
AB  - It has been observed that a fatty meal will cause a significant reduction in thiopental sleeping time in rabbits as well as rats. This reduction in sleeping time is not a non-specific phenomena as it does not occur with pentobarbital in rabbits. A similar reduction in sleeping time has been observed when an intravenous fat emulsion is administered to both rats and rabbits. The effect of both orally and intravenously administered fat is reversed by the administration of heparin in rabbits. Since heparin itself has no effect on the thiopental sleeping time in rabbits, it has been concluded that the fatty meal exerts its effect by virtue of the chylomicronemia that results from the absorption of the fat.