TY - JOUR T1 - THE METABOLIC CONVERSION OF 3-METHYL-5-ETHYL-5-PHENYL HYDANTOIN (MESANTOIN) AND OF 5-ETHYL-5-PHENYL HYDANTOIN (NIRVANOL) TO 5 - ETHYL -5- (<em>p</em>-HYDROXYPHENYL) HYDANTOIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 160 LP - 165 VL - 117 IS - 2 AU - Thomas C. Butler Y1 - 1956/06/01 UR - http://jpet.aspetjournals.org/content/117/2/160.abstract N2 - 5-Ethyl-5-(p-hydroxyphenyl) hydantoin ("p-hydroxynirvanol") has been found in the urine of dogs after the administration of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin) or 5-ethyl-5-phenyl hydantoin (Nirvanol). The same product has been isolated from the urine of a man receiving Mesantoin. The p-hydroxynirvanol from dog urine consists largely of the dextrorotatory isomer. That from human urine is optically inactive. The p-hydroxynirvanol in dog urine is largely conjugated with glucuronic acid. p-Hydroxynirvanol lacks the characteristic anesthetic activity of Nirvanol. The synthesis and the resolution of p-hydroxynirvanol are described. ER -