TY - JOUR T1 - A STUDY OF THE NEUROPHARMACOLOGIC PROPERTIES OF CERTAIN CONVULSANTS, ANTICONVULSANTS AND RESERPINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 142 LP - 147 VL - 117 IS - 2 AU - Graham Chen AU - Barbara Bohner Y1 - 1956/06/01 UR - http://jpet.aspetjournals.org/content/117/2/142.abstract N2 - The convulsant properties of NH4Ac, strychnine, picrotoxin, Metrazol, Coramine, and caffeine have been investigated by timed intravenous infusion in mice. Data on seizure patterns and on antagonism with various anticonvulsant agents under the influence of reserpine are presented to show how the convulsant effects of these agents may be clearly distinguished from one another by the difference in clonic and tonic-extensor seizure responses. In strychnine-, Metrazol- and caffeine-induced convulsive seizures, a comparative study was made of the anticonvulsant effects of Dilantin, phenobarbital, barbital, Milontin, PM 396, Phenurone, carbromal, Tolserol, and sodium bromide. The results are elucidated from the standpoint of a Dilantin-type, mephenesin-type or barbital-type anticonvulsant effect. Reserpine was found to have a suppressive effect on strychnine-induced tonic-extensor seizures and on Metrazol-induced clonic seizures in mice. This depressant action of reserpine was more pronounced when investigated jointly with barbital. ER -