RT Journal Article
SR Electronic
T1 THE EFFECT OF CERTAIN TRI-SUBSTITUTED PHOSPHINE OXIDES ON SYNAPTIC CONDUCTION IN THE ROACH
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 211
OP 220
VO 114
IS 2
A1 Kenneth D. Roeder
A1 Nancy K. Kennedy
YR 1955
UL http://jpet.aspetjournals.org/content/114/2/211.abstract
AB The effects of seven tri-substituted phosphine oxides have been studied on synaptic conduction in the last abdominal ganglion of the roach. The most active of these is methyl-(1-methyl-2,2-dimethyl-propoxy) fluorophosphine oxide. When applied directly to the ganglion it causes synaptic instability amid after-discharge in 5.7 x 10-11M solution. This effect is irreversible and probably due to inactivation of cholinesterase. Higher concentrations of the agent may cause a normal-appearing synchronized synaptic response and eventual synaptic block, effects which may be removed by washing with saline. Atropine, d-tubocurarine, scopolamine amid acetyicholine have little or no effect upon these changes produced by the phosphines. The phosphines abolish the stimulating effects of nicotine on the roach nerve-cord. The reversible effects of the phosphines on synaptic conduction could be due to competition with the mediator for the receptor.