PT  - JOURNAL ARTICLE
AU  - MARTIN M. WINBURY
AU  - MIRIAM L. HEMMER
TI  - ACTION OF QUINIDINE, PROCAINE AMIDE AND OTHER COMPOUNDS ON EXPERIMENTAL ATRIAL AND VENTRICULAR ARRHYTHMIAS IN THE DOG
DP  - 1955 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 402--413
VI  - 113
IP  - 4
4099  - http://jpet.aspetjournals.org/content/113/4/402.short
4100  - http://jpet.aspetjournals.org/content/113/4/402.full
SO  - J Pharmacol Exp Ther1955 Apr 01; 113
AB  - The action of quinidine, procaine amide and five SC-compounds on experimental atrial and ventricular arrhythmias was investigated. The SC-compounds are hydrochlorides of the following bases: SC-3920,N-(γ-isopropylaminopropyl)- α,α-diphenylacetamide; SC-3323, β-diisopropylaminoethyl-4-phenyl-4- tetrahydropyrancarboxylate; SC-3755, o-(4-chlorobenzyl)phenoxyacetamidine; SC-2919, N,N,N'-triphenyl-N'-(β-diethylaminoethyl)urea; and SC-3412, β-diethylaminoethyl-2, 6-dimethyl-5, 6-dihydro-4H-pyran-3-carboxylate. Atrial flutter was produced in dogs by injury and electrical stimulation of the atrium; atrial fibrillation was produced by direct application of aconitine. Ventricular arrhythmias were studied in unanesthetized dogs twenty-four hours after a two-step coronary ligation. The activity spectrum of the compounds differed and the compounds could be classified as follows: (a) active on atrial and ventricular arrhythmias (quinidine, procaine amide, SC-3920, SC-2919 and SC-3412; (b) active primarily on the atrium (SC-3323); and (c) active primarily on the ventricle (SC-3755). All of the compounds increased the “effective refractory period” of the isolated papillary muscle. © 1955, by The Williams & Wilkins Company