PT  - JOURNAL ARTICLE
AU  - MOYER, JOHN H.
AU  - HANDLEY, CARROLL A.
TI  - RENAL AND CARDIOVASCULAR HEMODYNAMIC RESPONSE TO GANGLIONIC BLOCKADE WITH PENDIOMIDE AND A COMPARISON WITH HEXAMETHONIUM AND ARFONAD
DP  - 1955 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 383--392
VI  - 113
IP  - 4
4099  - http://jpet.aspetjournals.org/content/113/4/383.short
4100  - http://jpet.aspetjournals.org/content/113/4/383.full
SO  - J Pharmacol Exp Ther1955 Apr 01; 113
AB  - Pendiomide in doses of 6 to 12 mgm./kgm. produces adequate ganglionic blockade to block the transmission of electrical stimuli along the vagus nerve. In this dosage range in dogs, Pendiomide is a relatively effective hypotensive agent. When Pendiomide is given in this concentration, renal vascular resistance decreases and renal blood flow, glomerular filtration rate, and the excretion of water and electrolytes are not altered appreciably. If glomerular filtration rate is depressed following ganglionic blockade and blood pressure reduction, norepinephrine will increase the blood pressure and return glomerular filtration rate towards the control values. This is usually associated with an increase in sodium and water excretion. © 1955, by The Williams & Wilkins Company