%0 Journal Article %A GEORGE T. OKITA %A PETER J. TALSO %A JOHN H. CURRY, JR. %A FREDERICK D. SMITH, JR. %A E. M. K. GEILING %T BLOOD LEVEL STUDIES OF C14-DIGITOXIN IN HUMAN SUBJECTS WITH CARDIAC FAILURE %D 1955 %J Journal of Pharmacology and Experimental Therapeutics %P 376-382 %V 113 %N 4 %X Using biosynthetically labeled C14 digitoxin, quantitative detection of micro amounts of unchanged digitoxin and its degradation products was accomplished. By the addition of non-labeled carrier digitoxin to the extraction mixture it is possible to isolate as little as 0.02 microgm. of radioactive digitoxin per sample of blood. Data have been presented on the blood level concentration, persistence and rate of disappearance of digitoxin from the blood stream of eight cardiac patients. © 1955, by The Williams & Wilkins Company %U https://jpet.aspetjournals.org/content/jpet/113/4/376.full.pdf