RT Journal Article
SR Electronic
T1 THE FATE OF PENTOBARBITAL IN MAN AND DOG AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 26
OP 34
VO 109
IS 1
A1 Brodie, Bernard B.
A1 Burns, J. J.
A1 Mark, Lester C.
A1 Lief, Philip A.
A1 Bernstein, Eleonore
A1 Papper, E. M.
YR 1953
UL http://jpet.aspetjournals.org/content/109/1/26.abstract
AB A method is described for the estimation of pentobarbital and other oxy-barbiturates in biological fluids and tissues. Pentobarbital is almost entirely metabolized in man. A major metabolic product is d-5-ethyl-5-(3-hydroxy-1-methylbutyl) barbituric acid. Unlike thiopental, pentobarbital is not extensively localized in body fat. This explains, in large part, why pentobarbital is not as short acting an anesthetic as thiopental. In man pentobarbital is metabolized more slowly than thiopental, whereas in the dog the reverse is true. This suggests that the two compounds are metabolized by different biochemical mechanisms.