PT  - JOURNAL ARTICLE
AU  - M. Jack Frumin
AU  - Herman Schwartz
AU  - J. J. Burns
AU  - Bernard B. Brodie
AU  - E. M. Papper
TI  - THE APPEARANCE OF PROCAINE IN THE SPINAL FLUID DURING PERIDURAL BLOCK IN MAN
DP  - 1953 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 102--105
VI  - 109
IP  - 1
4099  - http://jpet.aspetjournals.org/content/109/1/102.short
4100  - http://jpet.aspetjournals.org/content/109/1/102.full
SO  - J Pharmacol Exp Ther1953 Sep 01; 109
AB  - Segmental peridural anesthesia was produced in man by depositing 20 ml. of 2 per cent procaine at approximately the twelfth thoracic vertebral level. The concentration of procaine in the spinal fluid during the anesthesia was about 0.2 mgm. per ml., which is the threshold concentration for spinal block. At least part of the anesthesia during the peridural technique in man is the result of dural penetration of procaine and the subsequent production of spinal anesthesia.