PT  - JOURNAL ARTICLE
AU  - Sydney Ellis
AU  - Sibyl B. Beckett
TI  - THE ACTION OF EPINEPHRINE ON THE ANAEROBIC OR THE IODOACETATE-TREATED RAT'S DIAPHRAGM
DP  - 1954 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 202--209
VI  - 112
IP  - 2
4099  - http://jpet.aspetjournals.org/content/112/2/202.short
4100  - http://jpet.aspetjournals.org/content/112/2/202.full
SO  - J Pharmacol Exp Ther1954 Oct 01; 112
AB  - 1. At 27°C. under anaerobic conditions the rat's phrenic-diaphragm preparation contracted in response to direct electrical stimulation for many hours. In some preparations contraction of the muscle in response to indirect stimulation through the nerve was not completely suppressed by anaerobic conditions. 2. At 27°C. iodoacetate-poisoning sufficient to prevent anaerobic function of the diaphragm did not interfere with aerobic function. Bloom et al. (1953) have shown that an active non-glycolytic pathway for oxidative metabolism of glucose is not present in the rat diaphragm. 3. Neuromuscular block was produced by IAA-poisoning at 27°C. and neuromuscular transmission was restored by lactate or pyruvate. 4. The positive inotropic effect of epinephrine on the diaphragm was present in the anaerobic or the IAA-poisoned diaphragm. Possible sites of action eliminated by these observations are discussed.