TY - JOUR T1 - BLOOD SULFHYDRYL CHANGES IN METHEMOGLOBINEMIA, A POSSIBLE FACTOR IN PROTECTIVE EFFECTS OF NITRITE AND PARAMINOPROPIOPHENONE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 114 LP - 119 VL - 111 IS - 1 AU - Erwin P. Vollmer AU - Mary M. Carey Y1 - 1954/05/01 UR - http://jpet.aspetjournals.org/content/111/1/114.abstract N2 - The data show that two components of blood sulfhydryl, measured by methods devised for GSH and SH, behaved differently under certain experimental conditions: the concentration of the latter increased while that of the former decreased. This behavior occurred during methemoglobin formation, taking place both in vivo and in vitro when a direct methemoglobin-former (nitrite) was used, but only in vivo when an indirectly-acting agent (PAPP) was used. Some quantitative parallelism between the formation of methemoglobin and the formation of new SH groups was demonstrated. Alloxan, a poor methemoglobin former, significantly reduced the concentration of blood GSH without appreciably affecting the SH level. ER -