RT Journal Article SR Electronic T1 THE ROLE OF THE LIVER IN THE DEMETHYLATION OF N-METHYL DERIVATIVES OF HYDANTOIN AND OF 2,4-OXAZOLIDINEDIONE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 241 OP 243 VO 110 IS 2 A1 Thomas C. Butler A1 William J. Waddell YR 1954 UL http://jpet.aspetjournals.org/content/110/2/241.abstract AB Partial hepatectomy in the rat results in a large decrease in the rate of demethylation of l-Mesantoin and of trimethadione. It is concluded that the liver is the principal, if not the only, site of the demethylation of these drugs. The suggestion is made that the liver is probably the principal site of demethylation not only of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione but also of analogous compounds of other chemical types.